The difference between 2-wire, 3-wire, and 4-wire RTD temperature sensors lies in how they compensate for lead wire resistance, which affects measurement accuracy. A 2-wire RTD is the simplest configuration, where lead resistance adds directly to the sensor reading—suitable only for short cable runs or less critical applications. A 3-wire RTD adds a third lead to help offset lead resistance, making it the most common choice for industrial process control where good accuracy and cost efficiency are required. A 4-wire RTD offers the highest accuracy by fully eliminating the effect of lead resistance, even over long cable lengths, and is preferred in laboratories, calibration systems, and precision applications. Selecting between 2, 3, and 4-wire RTDs depends on installation distance, accuracy requirements, and budget, with each configuration offering a balance between simplicity, cost, and performance.